反应详情

1-Benzoyl-3-[1-(3-nitrobenzyl)piperid-4-yl]urea 4.47 g (from Example 13) was hydrogenated with 5% Pd/C (0.5 g) at atmospheric pressure and room temperature until no more hydrogen was taken up. The catalyst was filtered and the filtrate evaporated. The residue was dissolved in water and basified with 0.880 ammonia. The precipitated solid was filtered, washed well with water, dried, treated with charcoal, and evaporated to give the title compound, (1.9 gms). This was recrystallised from ethanolic HCl to give the dihydrochloride salt, monohydrate, m.p. 194°-195° C.

1. filtrationThe catalyst was filtered
2. customthe filtrate evaporated
3. dissolutionThe residue was dissolved in water and basified with 0.880 ammonia
4. filtrationThe precipitated solid was filtered
5. washwashed well with water
6. customdried
7. additiontreated with charcoal
8. customevaporated