反应详情

温度

70 °C

A solution containing 2.25 g (6.6 m moles) of 4-(4-chloro-1-naphthoxy)-3,5-dichloroaniline in 45 ml of toluene was placed under a nitrogen atmosphere and heated to 70° C. via an addition funnel was then added 1.82 g (9.9 m moles) of 2,6-difluorobenzoylisocyanate in 5 ml of toluene. The resulting mixture was then stirred at 70° C. for 45 min. and then cooled to room temperature. It was then cooled below 0° C. and filtered. The collected white white solid was dried under vacuum to afford 1.86 g of the desired product, m.p. 237°-239° C. NMR: (DMSO-d6): δ6.47 (d, J=8 Hz, 1H)- 7.0-8.6 (m, 10H), 10.40 (broad s, 1H), 11.60 (broad s, 1H).

1. temperaturecooled to room temperature
2. temperatureIt was then cooled below 0° C.
3. filtrationfiltered
4. customThe collected white white solid was dried under vacuum