HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-(N-methyl-N-phenylaminocarbonyl)piperazine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Carbamic chloride, N-methyl-N-phenyl- | HCID 77969 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 1-(N-methyl-N-phenylaminocarbonyl)piperazine hydrochloride | HCID 22591369 | — |
Reaction Steps
An acetonitrile (7 ml) solution containing N-(tert-butoxycarbonyl)piperazine (700 mg), N-methyl-N-phenylcarbamoyl chloride (700 mg) and triethylamine (1.05 mL) was stirred at room temperature for 15 hours to undergo reaction, and the resulting compound was acid-treated with hydrochloric acid to obtain 1-(N-methyl-N-phenylaminocarbonyl)piperazine.hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06849622B2 |
| Source dataset | uspto-grants-2005_02 |
| ORD ID | ord-e805a6f4dfc941a1bf33986745408cfb |
| Source note | uspto-grants-2005_02 |