tert-butyl N-[2-(2-benzyloxy-4-isopropylphenyl)ethyl]carbamate → 2-(2-Benzyloxy-4-isopropylphenyl)ethylamine hydrochloride

HRID 229580Notes

Reaction equation

HRID 229580 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([CH:15]([CH3:17])[CH3:16])[CH:12]=[CH:11][C:10]=1[CH2:18][CH2:19][NH:20]C(=O)OC(C)(C)C)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(O)C.[ClH:31]>C(O)C>[ClH:31].[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([CH:15]([CH3:17])[CH3:16])[CH:12]=[CH:11][C:10]=1[CH2:18][CH2:19][NH2:20])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 18457007tert-butyl N-[2-(2-benzyloxy-4-isopropylphenyl)ethyl]carbamateHCID 21887872Ethanol hydrochloride

Product 1

HCID 178562292-(2-Benzyloxy-4-isopropylphenyl)ethylamine hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 0.300 g of tert-butyl N-[2-(2-benzyloxy-4-isopropylphenyl)ethyl]carbamate in 2 mL of ethanol was added 2 mL of 21% hydrogen chloride ethanol solution at room temperature. After being stirred at the same temperature for 2 hours, the reaction mixture was concentrated under reduced pressure to give 0.261 g of 2-(2-benzyloxy-4-isopropylphenyl)ethylamine hydrochloride.

Workup

  1. concentrationthe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-3f3d7e3d099549ae825987b247a9d574
Source dataset
uspto-grants-2009_07
Patent number
US07563822B2

Reaction notes

Loading…