反应详情

To 1733 g of chlorosulfonic acid was added in small portions 150 g of 4-methoxybenzamide under ice-cooling with stirring during 15 minutes, and the mixture was stirred at room temperature for 14 hours. After being stirred at 50° C. for additional 1.5 hours, the reaction mixture was dropped into 7 kg of ice. The precipitate was collected by filtration, washed with water and hexane to give 230 g of 5-carbamoyl-2-methoxybenzenesulfonyl chloride.

1. temperaturecooling
2. stirringthe mixture was stirred at room temperature for 14 hours
3. stirringAfter being stirred at 50° C. for additional 1.5 hours
4. filtrationThe precipitate was collected by filtration
5. washwashed with water and hexane