Methanesulfonyl chloride → HCID 20474105, compound

Participants

Reaction Steps

Into a 50 ml round bottomed flask equipped with a calcium chloride drying tube and a magnetic stirrer were placed 5 ml of dry pyridine and 1 g of 2-(4'-chlorobenzyl)-hexahydro-1,2,4-triazine-3,5 dione. The mixture was then stirred and cooled in an ice bath, 0.5 g of methanesulfonyl chloride was added dropwise. After the product had been added the mixture was brought to ambient temperature and stirred for 5 hours. The solvent was then removed in vacuum and the residue was neutralized with dilute hydrochloric acid. The crystals obtained were filtered off and recrystallized from alcohol to yield 0.8 g of 1-methane sulfonyl-2-(4'-chlorobenzyl)-hexahydro-1,2,4-triazine-3,5-dione; m.p. 145°.

Provenance & Evidence