4-Chlorobenzoyl chloride → HCID 20474144, compound

HRID 2295833Notes

Reaction equation

HRID 2295833 reaction equation
[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([CH2:6][N:7]2[C:12](=[O:13])[NH:11][C:10](=[O:14])[CH2:9][NH:8]2)=[CH:4][CH:3]=1.[Cl:17][C:18]1[CH:26]=[CH:25][C:21]([C:22](Cl)=[O:23])=[CH:20][CH:19]=1>C1C=CC=CC=1>[Cl:17][C:18]1[CH:26]=[CH:25][C:21]([C:22]([N:8]2[CH2:9][C:10](=[O:14])[NH:11][C:12](=[O:13])[N:7]2[CH2:6][C:5]2[CH:15]=[CH:16][C:2]([Cl:1])=[CH:3][CH:4]=2)=[O:23])=[CH:20][CH:19]=1

Participants

4

Reactant 2

HCID 85014-Chlorobenzoyl chlorideHCID 20474130HCID 20474130, compound

Product 1

HCID 20474144HCID 20474144, compoundYield 60%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

Into a 100 ml round bottomed flask equipped with a reflux condenser sealed with a calcium chloride tube, were placed 100 ml of dry benzene, 1 g of 2-(4'-chlorobenzyl)-hexahydro-1,2,4-triazine-3,5-dione and 2 ml of p-chlorobenzoylchloride. The mixture was refluxed for 18 hours, the solution obtained was then cooled and the precipitated crystals were filtered off by suction to yield 1 g (60%) of 1-(4'-chlorobenzoyl)-2-(4'-chlorobenzyl)-hexahydro-1,2,4-triazine-3,5-dione; m.p. 205°.

Workup

  1. customInto a 100 ml round bottomed flask equipped with a reflux condenser
  2. customsealed with a calcium chloride tube
  3. temperatureThe mixture was refluxed for 18 hours
  4. customthe solution obtained
  5. temperaturewas then cooled
  6. filtrationthe precipitated crystals were filtered off by suction

Sources & evidence

ORD record
ord-53e45c7875d3492081ff8b24bb0d769b
Source dataset
uspto-grants-1984_01
Patent number
US04426522

Reaction notes

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