Water → 1,3,5-Triazine-2,4(1H,3H)-dione, 1-amino-3-(2,2-dimethylpropyl)-6-(ethylthio)-

Participants

Reaction Conditions

Reaction Steps

1.1 g of p-toluenesulphonic acid and 5.4 ml of water were added to a solution of 34.1 g (0.114 mol) of 1-isopropylideneamino-6-ethylthio-3-neopentyl-1,3,5-triazine-2,4(1H, 3H)-dione (the compound of formula (V-1)) in 150 ml of isopropanol at 60° C., and the mixture was stirred for one hour at 60° C., the bulk of the reaction product crystallizing out. Approximately 80 ml of the mixture were distilled off at 200 to 300 mbars, the mixture was cooled to 0° C. and was filtered under suction, and the residue was washed with a little methanol. 26.8 g (91% of theory) of 1-amino-6-ethylthio-3-neopentyl-1,3,5-triazine-2,4(1H, 3H)-dione of melting point 202° to 204° C. were obtained.

Provenance & Evidence