p-Toluenesulfonic acid → [2-Methyl-3-(pyrazin-2-yl)phenyl]methanol

Participants

Reaction Steps

A solution of 2.4 g (0.008 mol) of 2-methyl-3-(pyrazinyl)-benzenemethanol tetrahydropyranyl ether and 0.21 g of the pyridinium salt of 4-methylbenzenesulfonic acid in 35 mL of ethanol was warmed to 50° C.±5° C., and stirred for 24 hours. The reaction mixture was concentrated under reduced pressure, and the residue stirred for one hour with a mixture of 50 mL of methylene chloride and 50 mL of water. The organic layer was separated, dried, and concentrated under reduced pressure to give 1.6 g 2-methyl-3-(pyrazinyl)phenylmethanol as an oily solid residue.

Provenance & Evidence