Acetic Acid → HCID 20474272, compound

Participants

Reaction Steps

50.6 g (200 mmols) of the Na salt of 2-hydroxy-4-(4-ethyl-5-methyl-2H-1,2,3-triazol-2-yl)-benzaldehyde, 41.8 g (200 mmols) of ethyl 4-nitrophenylacetate and 2 ml of piperidine are refluxed in 250 ml of ethanol for 4 hours. After the mixture has been cooled, it is neutralised with glacial acetic acid, and the residue is washed with ethanol and water, and dried: 46.3 g (61.5%). Recrystallisation from toluene yields 41.4 g (55%) of 3-(4-nitrophenyl)-7-(4-ethyl-5-methyl-2H-1,2,3-triazol-2-yl)-coumarin in the form of a pale yellow crystalline powder of melting point 278°-279° C.

Provenance & Evidence