Sodium Iodide → HCID 13336614, compound

Participants

Reaction Steps

A solution of 3-[5-chloro-2-pyrimidyloxy]phenol (1.11 g), 2,4 dichlorobenzylchloride (0.98 g), potassium carbonate (0.76 g) and sodium iodide (0.075 g) in methyl ethyl ketone (25 ml) was refluxed for four hours. After dilution with water, the reaction mixture was extracted into chloroform and the extracts dried over anhydrous magnesium sulphate. Removal of the solvent under vacuum gave a white solid which was recrystallised from ethanol to give 1.45 g (77%) of the title compound, mp 110° C.

Provenance & Evidence