Bromotrimethylsilane → HCID 86739192, compound

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Reaction Steps

A solution of (S)-1,2,3,4-tetrahydro-2-[[ethoxy(4-phenylbutyl)phosphinyl]acetyl]-3-isoquinolinecarboxylic acid, phenylmethyl ester (1.07 g., 2.0 mmole) from Example 1(e) in dry dichloromethane (5 ml.) is treated with bromotrimethylsilane (0.4 ml., 3 mmole) and stirred at room temperature under argon for 16 hours. The mixture is evaporated to dryness and the residue is partitioned between ethyl acetate-water. The ethyl acetate phase is washed with saturated sodium chloride solution, dried (Na2SO4) and evaporated to give (S)-1,2,3,4-tetrahydro-2-[[hydroxy(4-phenylbutyl)phosphinyl]-acetyl]-3-isoquinolinecarboxylic acid, phenylmethyl ester.

Provenance & Evidence