HCID 86739194, compound → HCID 53878013, compound

Participants

Reaction Steps

A solution of the diester product from part (b) in methanol is added to a 10% palladium on carbon catalyst and the resulting mixture is shaken in a Parr hydrogenation apparatus for several hours. The catalyst is filtered off and the methanol stripped from the filtrate. The crude product is chromatographed on silica gel to yield (S)-1,2,3,4-tetrahydro-2-[[[(2,2-dimethyl-1-oxopropoxy)methoxy](4-phenylbutyl)-phosphinyl]acetyl]-3-isoquinolinecarboxylic acid.

Provenance & Evidence