Sodium borohydride → 3,3-Dimethyl-4-fluoro-1-(6-fluoro-pyridin-2-yl-oxy)-1-(1,2,4-triazol-1-yl)-butan-2-ol

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Reaction Steps

10 g (34 m moles) of 3,3-dimethyl-4-fluoro-1-(6-fluoro-pyridin-2-yl-oxy)-1-(1,2,4-triazol-1-yl)-butan-2-one (obtained as described in Example 1) were dissolved in 100 ml of methanol, and 0.7 g (17 m moles) of sodium borohydride was added. The mixture was stirred under reflux for 10 minutes and concentrated and the residue was partitioned between methylene chloride/water. The organic phase was separated off, washed with water, dried over sodium sulphate and concentrated. 9.3 g (90% of theory) of waxy 3,3-dimethyl-4-fluoro-1-(6-fluoro-pyridin-2-yl-oxy)-1-(1,2,4-triazol-1-yl)-butan-2-ol were obtained.

Provenance & Evidence