HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 3,4-Dimethyl-7-[3-(4-oximino-piperidino)-propoxy]-coumarin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 7-(3-Bromopropoxy)-3,4-dimethylcoumarin | HCID 14715356 | — |
| Reactant | N-(piperidin-4-ylidene)hydroxylamine hydrochloride | HCID 19106851 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3,4-Dimethyl-7-[3-(4-oximino-piperidino)-propoxy]-coumarin | HCID 20473354 | — |
Reaction Steps
By the reaction of 7-(3-bromopropoxy)-3,4-dimethylcoumarin with 4-oximino-piperidine hydrochloride in dioxane solution in the presence of a Hunig base, there is obtained 3,4-dimethyl-7-[3-(4-oximino-piperidino)-propoxy]-coumarin (m.p. 198°-200° C.), from which, by catalytic hydrogenation over Raney nickel in ammoniacal methanol, there is obtained 7-[3-(4-amino-piperidino)-propoxy]-3,4-dimethyl-coumarin; m.p. 92°-94° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04427680 |
| Source dataset | uspto-grants-1984_01 |
| ORD ID | ord-c686c1b9bfa24e14b0e73dada0cc9677 |
| Source note | uspto-grants-1984_01 |