N-[1-(3-Chloropropyl)piperidin-4-yl]benzamide → HCID 20473341, compound

HRID 2296002Notes

Reaction equation

HRID 2296002 reaction equation
[CH3:1][N:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([OH:12])[CH:10]=2)[C:5]([CH3:13])=[CH:4][C:3]1=[O:14].[C:15]([NH:23][CH:24]1[CH2:29][CH2:28][N:27]([CH2:30][CH2:31][CH2:32]Cl)[CH2:26][CH2:25]1)(=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>COC(O)C>[C:15]([NH:23][CH:24]1[CH2:29][CH2:28][N:27]([CH2:30][CH2:31][CH2:32][O:12][C:9]2[CH:10]=[C:11]3[C:6]([C:5]([CH3:13])=[CH:4][C:3](=[O:14])[N:2]3[CH3:1])=[CH:7][CH:8]=2)[CH2:26][CH2:25]1)(=[O:22])[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

4

Reactant 2

HCID 12799158N-[1-(3-Chloropropyl)piperidin-4-yl]benzamideHCID 221511942(1H)-Quinolinone,7-hydroxy-1,4-dimethyl-(9CI)

Product 1

HCID 20473341HCID 20473341, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 30156371-MethoxyethanolSolvent

Procedure

In a manner analogous to that described in Example 10, by the reaction of 1,4-dimethyl-7-hydroxy-2-oxo-1,2-dihydroquinoline with 3-(4-benzamidopiperidino)-propyl chloride in methoxyethanol, there is obtained, in a yield of 67% of theory, 7-[3-(4-benzamido-piperidino)-propoxy]-1,4-dimethyl-2-oxo-1,2-dihydroquinoline; m.p. 193°-195° C.

Sources & evidence

ORD record
ord-f8720065a9874406a89bac299fda34ab
Source dataset
uspto-grants-1984_01
Patent number
US04427680

Reaction notes

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