N-[1-(3-Chloropropyl)piperidin-4-yl]benzamide → 7-[3-(4-Benzamido-piperidino)-propoxy]-1-ethyl-4-methyl-2-oxo-1,2-dihydroquinoline

Participants

Reaction Steps

In a manner analogous to that described in Example 11, by the reaction of 1-ethyl-7-hydroxy-4-methyl-2-oxo-1,2-dihydroquinoline with 3-(4-benzamidopiperidino)-propyl chloride, there is obtained, in a yield of 59% of theory, 7-[3-(4-benzamido-piperidino)-propoxy]-1-ethyl-4-methyl-2-oxo-1,2-dihydroquinoline; m.p. 164°-165° C. (after recrystallization from dichloromethane/diethyl ether).

Provenance & Evidence