Cyclooctylamine → HCID 86739195, compound

Participants

Reaction Steps

A solution of 1-(methylthio)-1-[2-[[[5-(dimethylamino) methyl-2-furanyl]methyl]thio]ethylamino]2-nitroethene (1.05 g, 3.2 mmol) and cyclooctyl amine (1.2 g, 9.5 mmol) in ethanol (20 ml) was stirred at 20° C. for 21 days. The solvent was then removed in vacuo and the residue was chromatographed on a column of alumina (using chloroform as eluant) to give N-[2-[[[5-dimethylamino)-methyl-2-furanyl]methyl]thio]ethyl]-N'-cyclooctyl-2-nitro-1,1-ethenediamine (0.51 g, 39%) as an oil. [NMR τ (CDCl3) -0.30 br (s, 1H), 3.46 (s, 1H), 3.85 (s, 2H), 6.20 (s, 2H), 6.56 (s, 2H), 6.30-6.90 (m, 3H), 7.15-7.30 (m, 2H), 7.75 (s, 6H), 8.00-8.70 (m, 14H)]. [Found [M+H]+ 411.2391; C20H35N4O3S requires [M+H]+ 411.2429.]

Provenance & Evidence