Acetonitrile → HCID 70513664, compound

Participants

Reaction Steps

A solution of 2-[[[5-(dimethylamino)methyl-2-thienyl]methyl]thio]ethanamine (1.00 g) and 1-cyclooctylamino-1-methylthio-2-nitroethene (1.17 g) in acetonitrile (4 ml) was heated at reflux temperature for 8 days. The solvent was then evaporated in vacuo and the residue partitioned between water (25 ml) and ethyl acetate (25 ml). The aqueous phase was then extracted with ethyl acetate (2×25 ml) and the combined organic extracts were dried (Na2SO4) and evaporated in vacuo. The residue was purified by column chromatography on alumina using pentane/chloroform mixtures as eluant to give N-[2-[[5-(dimethylamino)methyl-2-thienyl]methyl]thioethyl]-N-cyclooctyl-2-nitro-1,1-ethenediamine (0.62 g) as an orange oil.

Provenance & Evidence