3-(3-Aminopropoxy)-N,N-dimethylbenzenemethanamine → HCID 67947014, compound

Participants

Reaction Steps

A solution of 3-[3-[(dimethylamino)methyl]phenoxy]-propylamine (0.28 g) and 1-cyclooctylamino-1-methylthio-2-nitroethene (0.36 g) in acetonitrile (5 ml) was heated at 80° for 10 days. The solvent was then evaporated in vacuo and the residue partitioned between water (15 ml) and chloroform (15 ml). The aqueous phase was then extracted with chloroform (2×25 ml) and the combined organic extracts were washed with brine (50 ml), dried (Na2SO4) and evaporated in vacuo. The residue was purified by column chromatography on alumina using pentane/chloroform mixtures as eluant to give N-[3-[3-[(dimethylamino)methyl]phenoxy]propyl]-2-nitro-1,1-ethenediamine (0.14 g) as an orange oil.

Provenance & Evidence