Hcl-butanol → HCID 178451322, compound

HRID 229609Notes

Reaction equation

HRID 229609 reaction equation
[CH2:1]([O:3][C:4](=[O:40])[CH2:5][O:6][C:7]1[CH:8]=[C:9]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=2[S:36]([CH3:39])(=[O:38])=[O:37])[CH:10]=[CH:11][C:12]=1[CH2:13][CH2:14][NH:15][S:16]([C:19]1[CH:24]=[C:23]([C:25](=[NH:28])[NH:26][OH:27])[CH:22]=[CH:21][C:20]=1[OH:29])(=[O:18])=[O:17])[CH3:2].[CH2:41](O)[CH2:42]CC.[ClH:46]>>[ClH:46].[OH:29][C:20]1[CH:21]=[CH:22][C:23]([C:25](=[NH:28])[NH:26][OH:27])=[CH:24][C:19]=1[S:16]([NH:15][CH2:14][CH2:13][C:12]1[CH:11]=[CH:10][C:9]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=2[S:36]([CH3:39])(=[O:37])=[O:38])=[CH:8][C:7]=1[O:6][CH2:5][C:4]([O:3][CH2:1][CH2:2][CH2:41][CH3:42])=[O:40])(=[O:18])=[O:17]

Participants

3

Reactant 2

HCID 22990708Hcl-butanolHCID 178472948HCID 178472948, compound

Product 1

HCID 178451322HCID 178451322, compound

Procedure

Method 1) A solution of 1.499 g of ethyl[4-[2-[2-hydroxy-5-(N-hydroxycarbamimidoyl)benzenesulfonylamino]ethyl]-2′-methanesulfonylbiphenyl-3-yloxy]acetate in 20 mL of 34% hydrogen chloride n-butanol solution was stirred at 60° C. for 3 hours. After being concentrated under reduced pressure, the reaction mixture was recrystallized from n-butanol-diisopropyl ether to give 1.472 g of n-butyl [4-[2-[2-hydroxy-5-(N-hydroxycarbamimidoyl)benzenesulfonylamino]ethyl]-2′-methanesulfonylbiphenyl-3-yloxy]acetate hydrochloride as a white crystal.

Workup

  1. concentrationAfter being concentrated under reduced pressure
  2. customthe reaction mixture was recrystallized from n-butanol-diisopropyl ether

Sources & evidence

ORD record
ord-20e722e5bb414b96a0f8c66242d76f18
Source dataset
uspto-grants-2009_07
Patent number
US07563822B2

Reaction notes

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