2H-1,2,4,6-Thiatriazine, 3-chloro-2-ethyl-5-methyl-, 1,1-dioxide → HCID 15583449, compound

Participants

Reaction Steps

19.8 parts of 30 percent strength sodium methylate were added to a solution of 20.95 parts of 3-chloro-2-ethyl-5-methyl-2H-1,2,4,6-thiatriazine-1,1-dioxide in 120 parts of tetrahydrofuran at 20°-25° C. in the course of 10 minutes, while stirring. The reaction mixture was stirred for three hours at 25° C. and then concentrated, the residue was taken up in ethyl acetate, and the solution was extracted twice with dilute sodium carbonate solution. The organic phase was separated off, dried and chromatographed over silica gel. The solution was then concentrated under reduced pressure, giving 14.5 parts of 2-ethyl-5-methyl-3-methoxy-2H-1,2,4,6-thiatriazine-1,1-dioxide of melting point 50°-53° C.

Provenance & Evidence