Sodium Chloride → HCID 13084599, compound

Participants

Reaction Steps

The intermediate 2,3-epoxypropoxy-4-(1,2,4-triazol-1-yl)-benzene is prepared in the following manner: 2.9 g (0.067 mole) of sodium hydride, as a 55% strength suspension in liquid paraffin, are introduced into 70 ml of anhydrous tetrahydrofuran, and a solution of 10.8 g (0.067 mole) of 4-(1,2,4-triazol-1-yl)-phenol in 50 ml of tetrahydrofuran is added dropwise. 9.2 g (0.067 mole) of epibromohydrin are then added dropwise. The reaction mixture is stirred for from 5 to 10 hours at room temperature and then poured onto 500 ml of aqueous sodium chloride solution, and the precipitate which separates out is filtered off under suction and washed thoroughly with water. The crude product is recrystallized from toluene/petroleum ether. 11.2 g (77%) of product of melting point 104°-105° C. are isolated.

Provenance & Evidence