Sodium Carbonate → HCID 86739200, compound

Participants

Reaction Steps

3-[2,3-Dihydro-2-benzofuranyl)propyl]-1,3-dithiane-2-carboxylic acid ethyl ester (8.0 g) dissolved in acetonitrile (15 mls) was added rapidly to a stirred solution of N-chlorosuccinimide (120 g) and silver nitrate (17.6 g) in 80% acetonitrile-water at 25° C. After 10 minutes saturated solutions of sodium sulphite (50 mls), sodium carbonate (50 mls) and brine were added successively at one minute intervals. To this mixture, a solution of hexane-dichloromethane (1:1, 250 mls) was added followed by filtration through celite. The organic phase of the filtrate was separated and dried over anhydrous magnesium sulphate. Removal of the solvent gave an oil (5.0 g). The unstable product was used immediately in the next stage. M/e M+ 262.

Provenance & Evidence