Diethyl (ethoxymethylene)malonate → HCID 13060483, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-amino-6-(4-methylpiperazinyl)quinazoline (2.19 g) and diethyl ethoxymethylenepropanedioate (2.13 g) in isobutylalcohol (9 ml) was stirred for 2 hours and 25 minutes at 100° C. and then cooled to ambient temperature. The resultant mixture was concentrated under reduced pressure to give a residue, which was recrystallized from ethanol to give crystalline diethyl [{6-(4-methylpiperazinyl)-4-quinazolinylamino}methylene]propanedioate (1.58 g).

Provenance & Evidence