HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → Dimethyl[[6-(2-ethylbutyramido)-4-quinazolinylamino]methylene]propanedioate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Dimethyl methoxymethylenemalonate | HCID 90770 | — |
| Reactant | 4-Amino-6-(2-ethylbutyramido)quinazoline | HCID 13060462 | — |
| Solvent | Water | HCID 962 | — |
| Product | Dimethyl[[6-(2-ethylbutyramido)-4-quinazolinylamino]methylene]propanedioate | HCID 13060503 | 56.1% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
A mixture of 4-amino-6-(2-ethylbutyramido)quinazoline (5.58 g), dimethyl methoxymethylenepropanedioate (5.62 g) and N,N-dimethylformamide (22 ml) was stirred at 100° C. for 1.5 hours. After cooling to ambient temperature, water (90 ml) was added to the reaction mixture. The resulting solid was separated by filtration, washed with water and dried to give dimethyl [[6-(2-ethylbutyramido)-4-quinazolinylamino]methylene]propanedioate (4.85 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04429126 |
| Source dataset | uspto-grants-1984_01 |
| ORD ID | ord-cea7b45ff99f4210a996cffd7049cf85 |
| Source note | uspto-grants-1984_01 |