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HRID 2296474作成日：2026年10月25日
Diethyl [[6-(2-ethylbutyramido)-4-quinazolinylamino]methylene]propanedioate → ethyl 4-oxo-10-(2-ethylbutyramido)-4H-pyrimido[1,2-C]quinazoline-3-carboxylate
https://huagongshe.com/reaction/2296474
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diethyl [[6-(2-ethylbutyramido)-4-quinazolinylamino]methylene]propanedioate | HCID 13060494 | — |
| 溶媒 | Diphenyl Ether | HCID 7583 | — |
| 生成物 | ethyl 4-oxo-10-(2-ethylbutyramido)-4H-pyrimido[1,2-C]quinazoline-3-carboxylate | HCID 13302088 | 93.4% |
反応手順
A mixture of diethyl [[6-(2-ethylbutyramido)-4-quinazolinylamino]methylene]propanedioate (0.6 g) in diphenyl ether (3 ml) was stirred at 250° C. for 15 minutes and cooled to ambient temperature. The resulting crystals were filtered, washed with ethyl acetate and dried. There was obtained ethyl 4-oxo-10-(2-ethylbutyramido)-4H-pyrimido[1,2-C]quinazoline-3-carboxylate (0.5 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US04429126 |
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| 出典データセット | uspto-grants-1984_01 |
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| ORD ID | ord-3e7e4d9ea35a45adae28e0592a5514a0 |
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| 出典メモ | uspto-grants-1984_01 |
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