Sodium Hydroxide → HCID 3080535, compound

HRID 2296490Notes

Reaction equation

HRID 2296490 reaction equation
[C:1]([C:3]1[C:4]([Br:16])=[C:5]([CH2:11][CH2:12][C:13]([OH:15])=[O:14])[C:6]([Br:10])=[CH:7][C:8]=1[Br:9])#[N:2].[OH-:17].[Na+]>O>[C:1]([C:3]1[C:4]([Br:16])=[C:5]([CH2:11][CH2:12][C:13]([OH:15])=[O:14])[C:6]([Br:10])=[CH:7][C:8]=1[Br:9])(=[O:17])[NH2:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 19848351HCID 19848351, compound

Product 1

HCID 3080535HCID 3080535, compoundYield 117.9%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
60 °C

Procedure

13 g of 3-(3-cyano-2,4,6-tribromophenyl)propionic acid is introduced into a solution of 3.2 g of caustic soda in 64 ml of water. The solution is then stirred for 3 hours at 60° C., filtered repeatedly over active carbon to decolorize, and subsequently the filtrate is brought to pH 1 by the addition of concentrated hydrochloric acid. The precipitate is vacuum-filtered, washed with water, and dried at 50° C., thus obtaining 16 g (95% of theory) of 3-(3-carbamoyl-2,4,6-tribromophenyl)propionic acid as a white powder, mp 197° C.

Workup

  1. filtrationfiltered repeatedly over active carbon
  2. additionsubsequently the filtrate is brought to pH 1 by the addition of concentrated hydrochloric acid
  3. filtrationThe precipitate is vacuum-filtered
  4. washwashed with water
  5. customdried at 50° C.

Sources & evidence

ORD record
ord-e64ecdfff59a48b091080159ed000bb1
Source dataset
uspto-grants-1984_01
Patent number
US04429152

Reaction notes

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