Phenol → 3,5-Dichloroaniline

Participants

Reaction Steps

131 parts of a tetrachloroaniline/pentachloroaniline mixture, 200 parts of phenol and 10 parts of 2-iodophenol are reacted in the presence of 12.5 parts of ruthenium-on-charcoal catalyst (5%) in a tantalum autoclave with hydrogen under a pressure of from 29 to 50 bars at a maximum temperature of 165° C., during the course of 8 hours, whilst stirring. 87.5 parts of 3,5-dichloroaniline are obtained after working up the reaction mixture. Yield: 95% of theory.

Provenance & Evidence