HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 4-[4-(2-Chloro-4-trifluoromethylphenoxy)phenoxy]-3-methoxy-2-pentenoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-[2-Chloro-4-(trifluoromethyl)phenoxy]phenol | HCID 12940613 | — |
| Reactant | Methyl 4-bromo-3-methoxypent-2-enoate | HCID 54279858 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 4-[4-(2-Chloro-4-trifluoromethylphenoxy)phenoxy]-3-methoxy-2-pentenoic acid | HCID 53860348 | — |
Reaction Steps
A mixture of 4-(2-chloro-4-trifluoromethylphenoxy)phenol (6.9 mmol.), methyl 4-bromo-3-methoxy-2-pentenoate (8.9 mmol.) and potassium carbonate (1.5 equis.) in acetone (15 ml.) is refluxed for 48 hours. After filtration, the filtrate was concentrated and the residue chromatographed on silica gel using 20% ethylacetate/hexane to give the methyl ester of 4-[4-(2-chloro-4-trifluoromethylphenoxy)phenoxy]-3-methoxy-2-pentenoic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04429167 |
| Source dataset | uspto-grants-1984_01 |
| ORD ID | ord-9be6fb362ca9460e9e8610a542ca5179 |
| Source note | uspto-grants-1984_01 |