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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2296546Generated: October 30, 2026

Methyl 3-oxo-4-(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)pentanoate → Methyl 3-hydroxy-4-(4-((5-(trifluoromethyl)-2-pyridinyl)oxy)phenoxy)valerate

https://huagongshe.com/reaction/2296546

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 3-oxo-4-(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)pentanoateHCID 179795—
ReactantSodium borohydrideHCID 4311764—
ReactantHCID 13472763HCID 13472763—
ProductMethyl 3-hydroxy-4-(4-((5-(trifluoromethyl)-2-pyridinyl)oxy)phenoxy)valerateHCID 179796—
ProductHCID 20252431HCID 20252431—

Reaction Steps

Each of the compounds, methyl 4-[4-(3,5-dichloropyridyloxy)phenoxy]-3-oxopentanoate and methyl 4-[4-(5-trifluoromethylpyridyloxy)phenoxy]-3-oxopentanoate is reacted with NaBH4 by the procedure of Example 17 to yield methyl 4-[4-(3,5-dichloropyridyloxy)phenoxy]-3-hydroxypentanoate and methyl 4-[4-(5-trifluoromethylpyridyloxy)phenoxy]-3-hydroxypentanoate, respectively.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04429167
Source datasetuspto-grants-1984_01
ORD IDord-2fc169e4e86049069ae8a43ab6ab1290
Source noteuspto-grants-1984_01