Tetrabutylammonium borohydride → HCID 70509211, compound

Participants

Reaction Steps

According to the procedures detailed in Example 3, benzhydryl 2-methyl-1-oxo-6-(2-phenoxyacetamido)carbapenam-3-carboxylate (138 mg., 0.28 mmole) in 15 ml. of methylene chloride was reduced with tetrabutylammonium borohydride (18 mg., 0.07 mmole) at -78° C., monitored and isolated as a washed, dried methylene chloride solution of benzhydryl 1-hydroxy-2-methyl-6-(2-phenoxyacetamido)carbapenam-3-carboxylate [Rf 0.24 (4:1 chloroform:ethyl acetate)]. If desired, the product is further isolated by evaporation to dryness in vacuo.

Provenance & Evidence