HCID 131712819, compound → HCID 70507886, compound

Participants

Reaction Steps

The pivaloyloxymethyl 2-methyl-6-(5-methyl-3-phenylisoxazole-4-carboxamido)-1-oxocarbapen-2-em-3-carboxylate of Example 35 was reduced with zinc (2.22 g.) in 5.3 ml. of acetic acid-30% tetrahydrofuran, by methods detailed in Example 2, and isolated according to methods detailed in Examples 2 and 32, affording pivaloyloxymethyl 2-methyl-6-(5-methyl-3-phenylisoxazole-4-carboxamido)-1-oxocarbapenam-3-carboxylate [100 mg., 50% over-all; ir (CH2Cl2) 1790, 1750, 1670 cm-1 ].

Provenance & Evidence