HCID 70507628, compound → HCID 70507018, compound

HRID 2296572Notes

Reaction equation

HRID 2296572 reaction equation
[CH:1]([O:14][C:15]([CH:17]([C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1)[C:18]([NH:20][CH:21]1[C:40](=[O:41])[N:23]2[CH:24]([C:29]([O:31][CH2:32][O:33][C:34](=[O:39])[C:35]([CH3:38])([CH3:37])[CH3:36])=[O:30])[CH:25]([CH3:28])[C:26](=[O:27])[C@H:22]12)=[O:19])=[O:16])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(OC(C(C1C=CC=CC=1)C(NC1C(=O)N2C(C(OCOC(=O)C(C)(C)C)=O)C(C)C(O)[C@H]12)=O)=O)C1C=CC=CC=1.OC1[C@@H]2C(NC(=O)C(C(OCC3C=CC4C(=CC=CC=4)C=3)=O)C3C=CC=CC=3)C(=O)N2C(C(OCOC(=O)C(C)(C)C)=O)C1C>>[CH:1]([O:14][C:15]([CH:17]([C:42]1[CH:43]=[CH:44][CH:45]=[CH:46][CH:47]=1)[C:18]([NH:20][CH:21]1[C:40](=[O:41])[N:23]2[CH:24]([C:29]([O:31][CH2:32][O:33][C:34](=[O:39])[C:35]([CH3:37])([CH3:38])[CH3:36])=[O:30])[CH:25]([CH3:28])[CH:26]([OH:27])[C@H:22]12)=[O:19])=[O:16])([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

4

Reactant 3

HCID 70507628HCID 70507628, compoundHCID 70508222HCID 70508222, compoundHCID 70508972HCID 70508972, compound

Product 1

HCID 70507018HCID 70507018, compound

Procedure

By the same method, the other 4-oxocarbapenam esters of Example 53 are converted to the corresponding pivaloyloxymethyl 6-(2-benzyloxycarbonyl-2-phenylacetamido)-1-hydroxy-2-methylcarbapenam-3-carboxylate and pivaloyloxymethyl 1-hydroxy-2-methyl-6-[2-(2-naphthylmethoxycarbonyl)-2-phenylacetamido]carbapenam-3-carboxylate.

Sources & evidence

ORD record
ord-dcdbd0cdf17646c0bbe13c032cbd0591
Source dataset
uspto-grants-1984_01
Patent number
US04429128

Reaction notes

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