HCID 18387483, compound → 4-Methyl-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-amine

HRID 2296609Notes

Reaction equation

HRID 2296609 reaction equation
[CH3:1][N:2]1[CH2:8][C:7]2[CH:9]=[C:10]([N+:13]([O-])=O)[CH:11]=[CH:12][C:6]=2[O:5][CH2:4][CH2:3]1>CO.[Pd]>[CH3:1][N:2]1[CH2:8][C:7]2[CH:9]=[C:10]([NH2:13])[CH:11]=[CH:12][C:6]=2[O:5][CH2:4][CH2:3]1

Participants

4

Reactant 1

HCID 18387483HCID 18387483, compound

Product 1

HCID 183874804-Methyl-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-amine

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 23938PalladiumSolvent

Procedure

4-Methyl-7-nitro-2,3,4,5-tetrahydro-1,4-benzoxazepine (1.52 g, 6.0 mmol) was dissolved in methanol (100 ml) and hydrogenated at 50 psi in the presence of a catalytic quantity of 10% Pd-C. After 1 h the mixture was filtered through glass and evaporated to an oil which was used immediately in the next step.

Workup

  1. filtrationAfter 1 h the mixture was filtered through glass
  2. customevaporated to an oil which

Sources & evidence

ORD record
ord-f8f3b2f6f6914b2cb60a729a3174097b
Source dataset
uspto-grants-2002_12
Patent number
US06489322B1

Reaction notes

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