Sodium Hydroxide → HCID 18387484, compound

Participants

Reaction Steps

To 2-[(2-fluoro-5-nitrobenzyl)(isopropyl)amino]ethanol (31.2 g, 90 mmol) in DMSO (250 ml) was added 25% sodium hydroxide solution (43.2 g, 270 mmol) and the mixture was allowed to stir for 3 h. The reaction was diluted to twice its volume with water and the solids were collected by filtration. The filtrate was extracted with methylene chloride (3×150 ml), washed with water, dried with magnesium sulfate, filtered, and concentrated to an oil. The solid and the oil were dissolved in hot 95% ethanol, then cooled. The solids were collected by filtration (17.47 g, 68%), MS m/z 237 [M+H]+.

Provenance & Evidence