化工社化工社 化学情報印刷レポート · 研究参考用
Water → Luminol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 反応物 | 1,4-Phthalazinedione, 2,3-dihydro-5-nitro- | HCID 3525223 | — |
| 反応物 | Luminol sodium salt | HCID 9794222 | — |
| 触媒 | Nickel | HCID 935 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | Luminol | HCID 10638 | — |
| 生成物 | Hydrazine hydrate (1:1) | HCID 24654 | — |
反応手順
This problem was solved by a method for manufacturing 5-amino-2,3-dihydrophthalazine-1,4-dione sodium salt, comprising reduction of the product by hydrazine hydrate in presence of a skeletal nickel catalyst, first by interacting 3-nitro-phthalanhydride with hydrazine hydrate in acetic acid at 90-120° C. with formation of 5-nitro-2,3-dihydrophthalazine-1,4-dione, after reduction thereof by hydrazine hydrate in a water-alkaline medium in presence of a skeletal nickel catalyst, isolating 5-amino-2,3-dihydrophthalazine-1,4-dione, which is then treated by sodium hydroxide in the presence of a lower alcohol or a ketone at 20-80° C. to obtain the target product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06489326B1 |
| 出典データセット | uspto-grants-2002_12 |
| ORD ID | ord-fe43f75a723949d6b88c3bf6b625f220 |
| 出典メモ | uspto-grants-2002_12 |