HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl pyrazinecarboxylate → Ethyl 1,4,5,6-tetrahydropyrazine-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl pyrazinecarboxylate | HCID 81341 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Solvent | HCID 178418361 | HCID 178418361 | — |
| Product | Ethyl 1,4,5,6-tetrahydropyrazine-2-carboxylate | HCID 18387556 | 102% |
Reaction Steps
A solution of ethyl pyrazine-2-carboxylate (60 g) in ETOH (500 ml) was subjected to catalytic reduction using palladium hydroxide on carbon (5.0 g), in hydrogen at 3 atm for 4 hours. The catalyst was removed by filtration and the filtrate was concentrated in vacuo to give 62.8 g of ethyl 1,4,5,6-tetrahydropyrazine-2-carboxylate as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06489324B2 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-aaa482584e4040f7accc379e3ad34645 |
| Source note | uspto-grants-2002_12 |