Acetic Anhydride → HCID 54414235, compound

Participants

Reaction Steps

Acetic anhydride (36 mg) was added to a solution of (2R)-4-(2-aminoethanesulfonyl)-N-tert-butoxy-1-tert-butoxycarbonyl-2-piperazinecarboxamide (130 mg) in AcOH (2 ml). The reaction mixture was stirred at ambient temperature for 3 hours. The mixture was concentrated in vacuo, and the residue was partitioned between AcOEt and saturated aqueous NaHCO3 solution. The organic layer was washed with saturated aqueous NaCl solution, dried over MgSO4, and concentrated in vacuo to give 142 mg of (2R)-4-[2-(acetylamino)-ethanesulfonyl]-N-tert-butoxy-1-tert-butoxycarbonyl-2-piperazinecarboxamide.

Provenance & Evidence