HCID 53729896, compound → HCID 53732363, compound

Participants

Reaction Steps

A mixture of (2R)-4-[2-(acetylamino)ethanesulfonyl]-N-tert-butoxy-1-[5-(4-fluorophenyl)thiophene-2-sulfonyl]-2-piperazinecarboxamide (130 mg) in anisole (1 ml), trifluoroacetic acid (1 ml) and H2O (0.02 ml) was stirred at ambient temperature overnight, and then at 50 ° C. for 5 hours. The mixture was concentrated in vacuo, and the residue was purified by SiO2 column chromatography, eluted with MeOH in CHCl3=2% then 5%. The fractions containing the desired product were combined and concentrated in vacuo. The residue was triturated with diisopropyl ether to give 88 mg of (2R)-4-[2-(acetylamino)ethanesulfonyl]-1-(5-(4-fluorophenyl)thiophene-2-sulfonyl]-N-hydroxy-2-piperazinecarboxamide.

Provenance & Evidence