Potassium Iodide → HCID 86758624, compound

Participants

Reaction Steps

A mixture of (2R)-4-(3-chloropropanesulfonyl)-1-[5-(4-fluorophenyl)thiophene-2-sulfonyl]-N-(2-tetrahydropyranyloxy)-2-piperazinecarboxamide (200 mg), piperidine (279 mg) and potassium iodide (65 mg) in DMF (3 ml) was stirred at ambient temperature for 2 days. The mixture was concentrated in vacuo. The residue was partitioned between AcOEt and H2O. The organic layer was washed with saturated aqueous NaCl solution, dried over MgSO4, and concentrated in vacuo. The residue was purified by SiO2 column chromatography eluted with MeOH in CHCl3 gradually from 0% to 5%, to give 165 mg of (2R)-1-[5-(4-fluorophenyl)thiophene-2-sulfonyl]-4-[3-(-piperidino) propanesulfonyl]-N-(2-tetrahydropyranyloxy)-2-piperazinecarboxamide.

Provenance & Evidence