HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 22596699, compound → HCID 22596732, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 22596699 | HCID 22596699 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 22596732 | HCID 22596732 | 103.5% |
Reaction Steps
A suspension of 5-amino-1-methyl-6-nitroquinazolin-2,4-dione (400 mg, 1.64 mmol) in MeOH (70 mL) was hydrogenated over 10% Pd/C (150 mg) in a Parr shaker at 50 psi until uptake ceased. The catalyst was removed by filtration and the filtrate concentrated to yield 5,6-diamino-1-methylquinazolin-2,4-dione (350 mg, 99% crude).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06489328B2 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-face90e345e54ebf82a2e619a7471a6d |
| Source note | uspto-grants-2002_12 |