HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-6-chlorobenzoic acid → 5-Chloroquinazolin-4(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-6-chlorobenzoic acid | HCID 75071 | — |
| Reactant | 1,2,3-Triazine | HCID 123047 | — |
| Catalyst | Piperidine | HCID 8082 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-Chloroquinazolin-4(1H)-one | HCID 135429916 | 70% |
Reaction Steps
A solution of 6-chloro anthranilic acid (2.12 g, 12.3 mmol) and triazine (1.0 g, 12.3 mmol) in EtOH (40 mL) containing piperidine (3 drops) was heated under reflux with stirring for 8 h. On cooling crystals formed, which were filtered to yield 5-chloroquinazolin-4-one (1.55 g, 70%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06489328B2 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-44ca4e1dec1f4e379aafc5828e0fef39 |
| Source note | uspto-grants-2002_12 |