Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | O-Xylene | HCID 7237 | — |
| Reactant | 5-Acetyloxy-2-chloropyridine | HCID 819930 | — |
| Reactant | HCID 22318968 | HCID 22318968 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | HCID 22319210 | HCID 22319210 | 38.4% |
Reaction Steps
3.42 g of 3-(2-cyanophenyl)-1-phenyl-5-(tri-n-butyl stannyl)-1,2-dihydropyridin-2-one, 1.57 g of 5-acetoxy-2-chloropyridine and 352 mg of tetrakistriphenylphosphine palladium were added to 40 ml of xylene, and the mixture was stirred at 120° C. in a nitrogen atmosphere for 8.5 hours. The reaction mixture was refined by silica gel chromatography (ethyl acetate/hexane-based solvent), to obtain 953 mg of the subject compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07563811B2 |
|---|
| Source dataset | uspto-grants-2009_07 |
|---|
| ORD ID | ord-ca518133d9e8477f8525bcc3884a338c |
|---|
| Source note | uspto-grants-2009_07 |
|---|
