Water → HCID 18387455, compound

Participants

Reaction Steps

2-Phenylbenzoyl chloride (0.36 g, 1.67 mM)(prepared from 2-biphenylcarboxylic acid as described in Example 3) was slowly added to a solution of Compound 12 as prepared in Example 7 (0.5 g, 1.4 mM) and triethylamine (0.38 ml, 3.3 mM)in methylene chloride (30 ml). The mixture was stirred at room temperature for 16 hours and water (80 ml) was added. The layers were separated. The methylene chloride layer was dried (MgSO4), filtered and evaporated in vacuo to give a crude product. Purification by flash column chromatography (EM silica gel 60; 30% EtOAc in CH2Cl2) yielded the desired product as a white solid. m/z (MH+) 536.

Provenance & Evidence