2-Methylbenzoyl chloride → HCID 18387467, compound

HRID 2296747Notes

Reaction equation

HRID 2296747 reaction equation
[CH3:1][N:2]([CH3:25])[CH2:3][CH2:4][CH:5]1[CH:11]=[CH:10][N:9]([C:12](=[O:20])[C:13]2[CH:18]=[CH:17][C:16]([NH2:19])=[CH:15][CH:14]=2)[C:8]2[CH:21]=[CH:22][CH:23]=[CH:24][C:7]=2[S:6]1.[C:26]1([CH3:35])[C:27]([C:32](Cl)=[O:33])=[CH:28][CH:29]=[CH:30][CH:31]=1.C1(C2C=CC=CC=2C(Cl)=O)C=CC=CC=1>>[CH3:25][N:2]([CH3:1])[CH2:3][CH2:4][CH:5]1[CH:11]=[CH:10][N:9]([C:12](=[O:20])[C:13]2[CH:18]=[CH:17][C:16]([NH:19][C:32](=[O:33])[C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=3[CH3:35])=[CH:15][CH:14]=2)[C:8]2[CH:21]=[CH:22][CH:23]=[CH:24][C:7]=2[S:6]1

Participants

4

Reactant 3

HCID 702762-Methylbenzoyl chlorideHCID 12563768[1,1'-Biphenyl]-2-carbonyl chlorideHCID 18387443HCID 18387443, compound

Product 1

HCID 18387467HCID 18387467, compound

Procedure

Compound 12 as prepared in Example 7 (0.118 mg, 0.37 mM) was treated following the procedure of Example 8, with 2-toluoyl chloride (0.04 ml, 0.33 mM) substituted for 2-phenylbenzoyl chloride, to give a white solid product. m/z (MH+) 474.

Workup

  1. additionwas treated
  2. customto give a white solid product

Sources & evidence

ORD record
ord-300b8e193dc2463fa4f1cf2aa8bf81b4
Source dataset
uspto-grants-2002_12
Patent number
US06489321B1

Reaction notes

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