Potassium Carbonate → HCID 70153605, compound

Participants

Reaction Steps

A mixture of Compound 28 as prepared in Example 14 (0.180 g, 0.36 mM), 2-(tert-butoxycarbonylaminoisobutyric acid (0.072 g, 0.36 mM), 1-hydroxybenzotriazole (0.05 g, 0.36 mM) and 1-[3-(dimethyamino)propyl]-3-ethylcarbodiimide hydrochloride (0.169 g, 0.9 mM) in methylene chloride (30 ml) was stirred at room temperature for 6 hours and a saturated potassium carbonate solution was added. Water was added and the layers were separated. The methylene chloride layer was dried (MgSO4), evaporated in vacuo and the resulting semi-solid purified by chromatography. The BOC group was removed with trifluoroacetic acid to give the desired amine. The HCl salt was prepared and recrystallized from methanol/diethyl ether to give the desired product as a white crystalline solid. m/z (MH+)593.

Provenance & Evidence