Benzoyl chloride, 2-chloro-4-[(5-fluoro-2-methylbenzoyl)amino]- → 2-(2-Hydroxyethyl)-5-[2-chloro-4-(2-methyl-5-fluorobenzoylamino)benzoyl]-1,5-benzothiazepine

Participants

Reaction Steps

A mixture of 2-(2-hydroxyethyl)-1,5-benzothiazepine as prepared in Example 2 (0.070 g, 0.34 mM) and N,O-bis(tri-methylsilyl)acetamide (0.15 ml, 0.67 mM)was treated as described in Example 3 with 2-Chloro-4-(2-methyl-5-fluorobenzoylamino)benzoyl chloride (0.11 g, 0.32 mM) substituted for 4-(2-phenylbenzoylamino)benzoyl chloride to give the product as a white solid. m/z (MH+) 500.

Provenance & Evidence