Methanol → HCID 70153550, compound

Participants

Reaction Steps

To a solution of 0.63 g (2.15 mmol) of 3-(RS)-(4-(4-fluorophenyl) piperidinylmethyl)-4-(SR)-hydroxyethylpyrrolidine and 0.6 mL (4.3 mmol) of Et3N in 20 mL of CH2Cl2 at 0° C. was added 0.32 mL (2.15 mmol) of 2-naphthoyl chloride and the reaction mixture was stirred for 1.2 h. To the reaction mixture was added 0.5 mL of MeOH and the reaction mixture was stirred 18 h at rt. The reaction mixture was concentrated and the residue was purified by chromatography (silica, acetone: hexanes, 1:2 to 1:1) to give 0.63 g of the title compound.

Provenance & Evidence