1-Methyl-1H-indole-7-carboxylic acid → 1-(1-Methyl-7-indolecarbonyl)-3-(RS)-(4-(4-fluorophenyl)piperidinylmethyl)-4-(SR)-(phenylhydroxymethyl)pyrrolidine

Participants

Role	Name	HCID	Charge
Reactant	1-Methyl-1H-indole-7-carboxylic acid	HCID 18388362	—
Reactant	3-(RS)-(4-(4-fluorophenyl)piperidinylmethyl)-4-(RS)-(phenylhydroxymethyl)pyrrolidine	HCID 18388375	—
Product	1-(1-Methyl-7-indolecarbonyl)-3-(RS)-(4-(4-fluorophenyl)piperidinylmethyl)-4-(SR)-(phenylhydroxymethyl)pyrrolidine	HCID 18723501	—

Reaction Steps

The title compound was prepared from 3-(RS)-(4-(4-fluorophenyl)piperidinylmethyl)-4-(RS)-(phenylhydroxymethyl)pyrrolidine and 1-methyl-7-indolecarboxylic acid according to procedures described in Example 39. The crude product was purified by chromatography (silica, acetone:hexane=1:2) to give the separate diastereomers of the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06489354B1
Source dataset	uspto-grants-2002_12
ORD ID	ord-f31d97ff9035449c903a415cab29999b
Source note	uspto-grants-2002_12